In this trailer, Wade (wearing a wig) is having a birthday party with the supporting cast of his previous films: his girlfriend Vanessa (Morena Baccarin), the steel-skinned X-Man Colossus (voiced Stefan Kapičić), Wade’s roommate Blind Al (Leslie Uggams), and more. However, the reunion is short-lived because agents from the Time Variance Authority (TVA) come knocking on Wade’s door and abduct him.
The TVA is an interdimensional organization that “prunes” deviations from the Sacred Timeline (aka the sequence of events shown in the MCU films). Hostile variants are thrown into the Void, a wasteland at the end of time, to be devoured by a malevolent storm called Alioth. The TVA was in truth founded by a variant of the villainous Kang (Jonathan Majors) called “He Who Remains,” who wanted to prevent his other selves from traveling and warring across the multiverse.
“Loki” followed the titular God of Mischief (Tom Hiddleston) as he was recruited into the TVA. Specifically, this was the Loki from “Avengers: Endgame” who, thanks to some time travel, wound up escaping his arrest at the end of “The Avengers.” The series ended with Loki sacrificially becoming the God of Stories, living in a void of solitude while harmoniously weaving together different timelines. Meanwhile, the TVA shifted its mission specifically to combat Kang.
No TVA agents from “Loki” appear in the trailer, not even hologram mascot Miss Minutes (Tara Strong). Instead, Wade meets the previously-unseen Paradox (Matthew Macfadyen), who tells Deadpool that he’s “very important” — if this is a post “Loki” TVA, this might be part of their conflict with Kang, and a set-up for his clash with the Avengers. As Majors was dropped from the role due to his legal troubles, the specifics remain unknown (for the public anyway).